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Article History

Received: 11 February 2021

Accepted: 7 May 2021

First Online: 2 June 2021

Declarations

:

: Animal handling for the antibody production was carried out strictly according to the procedures outlined in the NIH (USA) Guide for the Care and Use of Laboratory Animals. The protocols used were approved by the Committee on Bioethics of the Institute of Gene Biology, Russian Academy of Sciences. All procedures were performed under the supervision of a licensed veterinarian, under conditions that minimize pain and distress.Rabbits were purchased from a licensed specialized nursery, and Manihino. Soviet chinchilla rabbits used in the study are not endangered or protected. Only healthy rabbits certified by a licensed veterinarian were used. The rabbits were individually housed in standard size, stainless steel rabbit cages and provided ad libitum access to alfalfa hay, commercial rabbit food pellets, and water. The appetite and behavior of each rabbit were monitored daily by a licensed veterinarian. Body weight and temperature of each rabbit were evaluated prior to and daily following immunization. No animals became ill or died at any time prior to the experimental endpoint. At the end of the study period, all rabbits were euthanized by intravenous injection of barbiturate anesthetics.

: Not applicable.

: The authors declare that they have no competing interests.