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Article History

Received: 10 December 2021

Accepted: 12 July 2022

First Online: 22 October 2022

Declarations

:

: The human blood used in this work was from voluntary donors and commercially obtained from the <i>Banc de Sang i Teixits</i> (www.bancsang.net). Blood was not collected specifically for this research; the purchased units had been discarded for transfusion, usually because of an excess of blood relative to anticoagulant solution. Prior to their use, blood units underwent the analytical checks specified in the current legislation. Before being delivered to us, unit data were anonymized and irreversibly dissociated, and any identification tag or label had been removed in order to guarantee the non-identification of the blood donor. No blood data were or will be supplied, in accordance with the current Spanish <i>Ley Orgánica de Protección de Datos</i> and <i>Ley de Investigación Biomédica</i>. The blood samples will not be used for studies other than those made explicit in this research.For in vivo assays, in the presence of toxic effects including, among others, > 20% reduction in weight, aggressive and unexpected animal behavior or the presence of blood in feces, animals were immediately anesthetized using a 100 mg/kg ketamine plus 10 mg/kg xylazine mixture and sacrificed by cervical dislocation. The PCB animal facility has the relevant authorizations as approved establishment of breeding, supplier, and user (B9900044 and REGA code: ES080190036527) to work with vertebrate animals used for experimental and scientific purposes. The animal care and use protocols followed adhered to the specific national and international guidelines in accordance with the current Catalan (D 214/1997/GC) and Spanish laws (RD 53/2013; order ECC/566/2015) and the corresponding European Directive (2010/63 EU).

: Not applicable.

: A patent application (EP21382949.2) has been filed to protect some of the results presented in the paper, which includes as inventors IB-A, AB, DM-T, and XF-B. All other authors declare they have no competing interests.