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LMO7-mediated ubiquitination of SIRT3 promotes osteoarthritis progression: an investigation using machine learning and molecular dynamics simulations

Crossref DOI link: https://doi.org/10.1186/s12915-026-02587-7

Published Online: 2026-04-16

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Zhang, Qian https://orcid.org/0000-0002-5228-6851
Li, Jun https://orcid.org/0000-0003-1227-6939
Shan, Guangchang https://orcid.org/0009-0009-0725-7996
Huang, Dongfeng https://orcid.org/0000-0002-7958-4082
Funding

Funding for this research was provided by:

Medical Research Science and Technology Foundation of Guangdong Province (A2024023)

the Hospital Research Fund of SAHSYSU (00302510081)

National Natural Science Foundation of China (82202609)

Natural Science Foundation of Guangdong Province (2414A1515012911)

Fundamental Research Funds for the Central Universities, Sun Yat-sen University (24pnpy240)
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Text and Data Mining valid from 2026-04-16

Version of Record valid from 2026-05-26
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Article History

Received: 28 May 2025

Accepted: 24 March 2026

First Online: 16 April 2026

Declarations

:

: The Medical Ethics Committee of the Seventh Affiliated Hospital of Sun Yat-sen University approved the human-related research of this study (No. KY-2024–115-01), with written informed consent obtained from all participants, and the study conformed to the principles of the Declaration of Helsinki. The Institutional Animal Care and Use Committee of Sun Yat-sen University approved the animal experimental protocol (No. SYSU-IACUC-2024-B0841), with all experiments performed in accordance with the ethical standards of the institutional ethics committee and the NC3Rs ARRIVE guidelines.

: Not applicable.

: The authors declare no competing interests.

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