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Article History

Received: 11 July 2021

Accepted: 21 October 2021

First Online: 1 December 2021

Declarations

:

: The collection of human tissues was approved by the Medical Ethics Committee at the Uppsala University Hospital (No. C254/4, C209/10, C45/7, No. 99398, 22/9 1999, cont., 2003, Dnr. 2013/190). Patients’ consent for their participation was obtained. The study adheres to the rules of the Declaration of Helsinki. Ethical approval for the UK Biobank was granted by the North West Multi-centre Research Ethics Committee (MREC), the National Information Governance Board for Health & Social Care (NIGB), and Community Health Index Advisory Group (CHIAG). Ethical approval for the use of UK Biobank data in our study was also granted by the Swedish Ethical Review Authority (dnr: 2020-04415).

: Not applicable.

: MED-EL Medical Electronics, R&D, GmbH, and Innsbruck, Austria, provided salary support for one research group member (Wei Liu) in accordance with the contract agreement with Uppsala University, Sweden 2018. Mathias Rask-Andersen has provided consulting services to Olink Proteomics. All remaining authors have no conflict of interest. The funders were not involved in the study design, collection, analysis, and interpretation of data, the writing of this article or the decision to submit it for publication.