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Authors
Yang, Qian https://orcid.org/0000-0001-8778-4132
Magnus, Maria C.
Kilpi, Fanny
Santorelli, Gillian
Soares, Ana Gonçalves
West, Jane
Magnus, Per
Wright, John
Håberg, Siri Eldevik
Sanderson, Eleanor
Lawlor, Deborah A.
Tilling, Kate
Borges, Maria Carolina
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Funding
Funding for this research was provided by:
China Scholarship Council (CSC201808060273)
Medical Research Council (MM_UU_00011/1, MM_UU_00011/3, MM_UU_00011/6, MR/P014054/1, 217065/Z/19/Z, MR/N024397/1, G0600705)
National Institutes of Health (R01DK10324)
British Heart Foundation (AA/18/7/34219, CS/16/4/32482, CH/F/20/90003)
European Research Council (947684)
Norges Forskningsråd (320656, 262700)
Horizon 2020 (874739)
National Institute for Health Research (NF-0616-10102, NF-SI-0611-10196)
Wellcome Trust (WT088806, WT101597MA)
FP7 Ideas: European Research Council (669545)
Wellcome Trust (WT223601/Z/21/Z)
National Institute for Health Research Collaboration for Leadership in Applied Health Research and Care Yorkshire and Humber (NIHR200166)
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Article History
Received: 7 February 2022
Accepted: 25 July 2022
First Online: 12 September 2022
Declarations
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: Ethical approval for UKB was obtained from the North West Multi-centre Research Ethics Committee. Ethical approval for the study was obtained from the ALSPAC Ethics and Law Committee and the Local Research Ethics Committees. Consent for biological samples has been collected in accordance with the Human Tissue Act (2004). Informed consent for the use of data collected via questionnaires and clinics was obtained from participants following the recommendation of the ALSPAC Ethics and Law Committee at the time. Ethical approval for BiB was obtained from the Bradford Research Ethics Committee. The establishment of MoBa and initial data collection was based on a license from the Norwegian Data Protection Agency and approval from The Regional Committees for Medical and Health Research Ethics. The MoBa cohort is now based on regulations related to the Norwegian Health Registry Act. The current study was approved by The Regional Committees for Medical and Health Research Ethics. The Coordinating Ethics Committee of the Helsinki and Uusimaa Hospital District has approved the FinnGen consortium (Nr HUS/990/2017), and this study used its summary level data.
: Not applicable.
: KT has acted as a consultant for CHDI Foundation, and Expert Witness to the High Court in England, called by the UK Medicines and Healthcare products Regulatory Agency, defendants in a case on hormonal pregnancy tests and congenital anomalies 2021/22. DAL is an editorial advisor for <i>BMC Medicine</i> and has received support from Medtronic LTD and Roche Diagnostics for biomarker research that is not related to the study presented in this paper. The other authors declare no competing interests.
