Cavazos, Taylor B.
Kachuri, Linda
Graff, Rebecca E.
Nierenberg, Jovia L.
Thai, Khanh K.
Alexeeff, Stacey
Van Den Eeden, Stephen
Corley, Douglas A.
Kushi, Lawrence H.
,
Abecasis, Goncalo
Baras, Aris
Cantor, Michael
Coppola, Giovanni
Deubler, Andrew
Economides, Aris
Karalis, Katia
Lotta, Luca A.
Overton, John D.
Reid, Jeffrey G.
Siminovitch, Katherine
Shuldiner, Alan
Beechert, Christina
Forsythe, Caitlin
Fuller, Erin D.
Gu, Zhenhua
Lattari, Michael
Lopez, Alexander
Overton, John D.
Padilla, Maria Sotiropoulos
Pradhan, Manasi
Manoochehri, Kia
Schleicher, Thomas D.
Widom, Louis
Wolf, Sarah E.
Ulloa, Ricardo H.
Averitt, Amelia
Banerjee, Nilanjana
Cantor, Michael
Li, Dadong
Malhotra, Sameer
Sharma, Deepika
Staples, Jeffrey
Bai, Xiaodong
Balasubramanian, Suganthi
Bao, Suying
Boutkov, Boris
Chen, Siying
Eom, Gisu
Habegger, Lukas
Hawes, Alicia
Khalid, Shareef
Krasheninina, Olga
Lanche, Rouel
Mansfield, Adam J.
Maxwell, Evan K.
Mitra, George
Nafde, Mona
O’Keeffe, Sean
Orelus, Max
Panea, Razvan
Polanco, Tommy
Rasool, Ayesha
Reid, Jeffrey G.
Salerno, William
Staples, Jeffrey C.
Sun, Kathie
Xin, Jiwen
Abecasis, Goncalo
Backman, Joshua
Damask, Amy
Dobbyn, Lee
Ferreira, Manuel Allen Revez
Ghosh, Arkopravo
Gillies, Christopher
Gurski, Lauren
Jorgenson, Eric
Kang, Hyun Min
Kessler, Michael
Kosmicki, Jack
Li, Alexander
Lin, Nan
Liu, Daren
Locke, Adam
Marchini, Jonathan
Marcketta, Anthony
Mbatchou, Joelle
Moscati, Arden
Paulding, Charles
Sidore, Carlo
Stahl, Eli
Watanabe, Kyoko
Ye, Bin
Zhang, Blair
Ziyatdinov, Andrey
Jones, Marcus B.
Mighty, Jason
Mitnaul, Lyndon J.
Hoffmann, Thomas J.
Ziv, Elad
Habel, Laurel A.
Jorgenson, Eric
Sakoda, Lori C.
Witte, John S.
Funding for this research was provided by:
National Institutes of Health (R01 CA201358, RC2 AG036607)
National Science Foundation (1650113)
National Cancer Institute (K99CA246076)
Article History
Received: 16 March 2022
Accepted: 17 August 2022
First Online: 6 October 2022
Declarations
:
: The research was conducted with approved access to UK Biobank data under application number 14105 (PI: Witte) and in accordance with the UK Biobank Ethics and Governance Framework. UK Biobank data are publicly available by request from . The de-identified participants from the Kaiser Permanente Research Bank were obtained with approval under UCSF IRB number 16-19699 (PI: Witte). Access to and use of data from the Kaiser Permanente Research Bank (KPRB) were approved by the KPRB Access Review Committee. The study was conducted under a waiver of informed consent approved by the Kaiser Permanente Northern California Institutional Review Board. All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients, or participants themselves) outside the research group so cannot be used to identify individuals.
: Not applicable
: J.S. Witte is a non-employee, cofounder of Avail Bio. E. Jorgenson and additional authors listed under “Regeneron Genetics Center” are full-time employees of Regeneron Pharmaceuticals. No disclosures were reported for the other authors.