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Identification and validation of an explainable machine learning model for vascular depression diagnosis in the older adults: a multicenter cohort study

Crossref DOI link: https://doi.org/10.1186/s12916-025-04283-9

Published Online: 2025-07-31

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Zhang, Ran

Li, Tian

Fan, Fan

He, Haoying

Lan, Liuyi

Sun, Dong

Xu, Zhipeng

Peng, Sisi

Cao, Jing

Xu, Juan

Peng, Xiaoxiang

Lei, Ming

Song, Hao

Zhang, Junjian
Funding

Funding for this research was provided by:

National Key Research and Development Program of China (2021YFC2500102, 2021YFC2500102, 2021YFC2500102, 2021YFC2500102, 2021YFC2500102, 2021YFC2500102, 2021YFC2500102, 2021YFC2500102, 2021YFC2500102, 2021YFC2500102, 2021YFC2500102, 2021YFC2500102, 2021YFC2500102, 2021YFC2500102)

Zhongnan Hospital of Wuhan University Medical Science and Technology Innovation Platform Support Project (PTXM2020006, PTXM2020006, PTXM2020006, PTXM2020006, PTXM2020006, PTXM2020006, PTXM2020006, PTXM2020006, PTXM2020006, PTXM2020006, PTXM2020006, PTXM2020006, PTXM2020006, PTXM2020006)

Hubei Provincial Clinical Research Center for Dementia and Cognitive Impairment (PTYX2024024, PTYX2024024, PTYX2024024, PTYX2024024, PTYX2024024, PTYX2024024, PTYX2024024, PTYX2024024, PTYX2024024, PTYX2024024, PTYX2024024, PTYX2024024, PTYX2024024, PTYX2024024)
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Text and Data Mining valid from 2025-07-31

Version of Record valid from 2025-07-31
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Article History

Received: 15 November 2024

Accepted: 15 July 2025

First Online: 31 July 2025

Declarations

:

: This study was performed with ethical approval of the Ethics Committee (ClinicalTrials.gov; ID: NCT04999813) and the Medical Ethics Committee, Zhongnan Hospital of Wuhan University (ID: 2020124). All participants provided written informed consent in line with the Declaration of Helsinki.

: Not applicable.

: The authors declare no competing interests.

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