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Authors
Wang, Shuang
Xu, Le
Jiao, Xue
Dong, Xiaoyu
Zhong, Zhaoyang
Ren, Qianhui
Liu, Xiaoxuan
Yuan, Ming
Wang, Guoyun
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Funding
Funding for this research was provided by:
The National Key R&D Program of China (2022YFC2704000)
the Special foundation for Taishan Scholars (No. tstp20230657)
the Major Basic Research of Natural Science Foundation of Shandong (ZR2021ZD34)
the National Natural Science Foundation of China (82371653)
General Project of Shandong Natural Science Foundation (ZR2023MH177)
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Article History
Received: 10 January 2025
Accepted: 29 August 2025
First Online: 27 October 2025
Declarations
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: The studies involving the collection of clinical samples was approved by the Ethics Committee of the Medical Integration and Practice Center of Shandong University (SDULCLL2022-1-21; approval date: 4 November 2022). All participants gave their consent to participate prior to the inclusion in the study. The ethics approval statements for animal work were provided by the Ethics Committee of the Medical Integration and Practice Center of Shandong University (SDULCLL2022-2-17; approval date: 4 November 2022). The study was conducted in strict compliance with the requirements of the “Animals (Scientific Procedures) Act 1986” and adhered to the 3R principles (Refinement, Replacement, Reduction).
: Not applicable.
: The authors declare no competing interests.
