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Authors
Harada, Makoto
Adam, Jonathan
Han, Siyu
Shi, Mengya
Ge, Jianhong
Lintelmann, Jutta
Cecil, Alexander
Zukunft, Sven
Prehn, Cornelia
Witting, Michael
Scheerer, Markus F.
Neschen, Susanne
Irmler, Martin
Beckers, Johannes
Adamski, Jerzy
Teupser, Daniel
Linkohr, Birgit
Gieger, Christian
de Angelis, Martin Hrabě
Peters, Annette
Wang-Sattler, Rui
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Funding
Funding for this research was provided by:
Uehara Memorial Foundation
Bavarian State Ministry of Health, Care and Prevention (DigiMed Bayern)
German Federal Ministry of Education and Research (DZD)
German Federal Ministry of Education and Research (KORA)
Innovative Medicines Initiative 2 (No. 821508 (CARDIATEAM))
Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
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Article History
Received: 18 July 2025
Accepted: 26 December 2025
First Online: 8 January 2026
Declarations
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: The KORA-Fit study protocols were approved by the Ethics Committees of the Bavarian Chamber of Physicians (KORA-Fit EC No. 17040) and were conducted in accordance with the Declaration of Helsinki. All participants provided written informed consent.The mouse experiments were approved by the Government of Upper Bavaria (approval numbers: Gz.55.2–1-54–2531-70–07, 55.2–1-2532–153-11).
: Not applicable. The manuscript contains no data that could identify any individual participant; hence, consent for publication is not necessary.
: Markus F. Scheerer was employed at Helmholtz Zentrum München during his PhD thesis and was recently employed in the CardioRenal Medical Department of Bayer AG, however, the company was not involved in work related to data and manuscript generation. Susanne Neschen was employed by the Helmholtz Zentrum München during the execution of this study. She is currently an employee of Sanofi Aventis Deutschland GmbH. However, this company was not involved in work related to data and manuscript generation.
