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Article History

Received: 8 December 2025

Accepted: 11 March 2026

First Online: 16 March 2026

Declarations

:

: Human tissue and blood-sample collection was approved by the Human Ethics Committee of Guangzhou First People’s Hospital (K-2019–156–02), and written informed consent was obtained from all participants prior to sample collection. All animal experiments were approved by the Animal Ethics Committee of Fuwai Hospital (approval No. 0108–7-800-ZX(X)-019) and complied with institutional and national guidelines for the care and use of laboratory animals.

: All authors have read and approved the final manuscript and consent to its publication.

: The authors declare that they have no competing interests.