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Authors
Siriarchavatana, Parkpoom
Oontawee, Saranyou
Rodprasert, Watchareewan
Thongsit, Anatcha
Somparn, Poorichaya
Na Nan, Daneeya
Nedumpun, Teerawut
Osathanon, Thanaphum
Egusa, Hiroshi
Srisuwatanasagul, Sayamon
Sawangmake, Chenphop
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Funding
Funding for this research was provided by:
Second Century Fund (C2F), Chulalongkorn University
Thailand Science Research and Innovation Fund Chulalongkorn University
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Article History
Received: 2 February 2025
Accepted: 1 September 2025
First Online: 10 October 2025
Declarations
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: This study adhered to the ARRIVE guidelines and ethical standards established by the Institutional Animal Care and Use Committee (IACUC) of the Faculty of Veterinary Science, Chulalongkorn University, Thailand. The research was conducted under two distinct Animal Use Protocols, ensuring compliance with ethical standards and institutional guidelines. Approval for the collection of adipose tissue used in sEV preparation was granted under Animal Use Protocol 2231041. Adipose tissue was collected from a privately owned donor animal with the informed consent of the owner, following ethical procedures for the humane treatment of animals. The biodistribution study and experimental procedures were approved under Animal Use Protocol 2473005. This protocol covered all aspects of animal care and experimental interventions, including acclimatization, intravenous administration of labeled sEVs, blood collection, and organ harvesting. The IACUC operates as an independent entity, ensuring an unbiased and rigorous review process. All experimental processes prioritized animal welfare, adhering strictly to ethical and institutional standards.
: Not applicable.
: The authors declare no competing interests.
