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Article History

Received: 12 October 2018

Accepted: 17 October 2018

First Online: 27 November 2018

Authors’ information

: <b>Consortium members</b>Stephan Beck^{1, 2, 3}, Alison M Berner¹, Graham Bignell⁴, Maggie Bond⁴, Martin J Callanan⁴, Olga Chervova¹, Lucia Conde⁵, Manuel Corpas^{4, 6}, Simone Ecker¹, Hannah R Elliott^{7, 8}, Silvana A Fioramonti¹, Adrienne M Flanagan⁹, Ricarda Gaentzsch¹⁰, David Graham¹¹, Deirdre Gribbin⁴, José Afonso Guerra-Assunção⁵, Rifat Hamoudi^{12, 13}, Vincent Harding¹⁴, Paul L Harrison¹⁵, Javier Herrero⁵, Jana Hofmann¹⁶, Erica Jones⁴, Saif Khan¹², Jane Kaye^{17, 18}, Polly Kerr¹⁹, Emanuele Libertini¹, Lauren Marks²⁰, Laura McCormack²¹, Ismail Moghul¹, Nikolas Pontikos⁴, Sharmini Rajanayagam²², Kirti Rana⁵, Momodou Semega-Janneh⁴, Colin P Smith^{4, 23}, Louise Strom²⁴, Sevgi Umur¹, Amy P Webster¹, Elizabeth H Williams¹⁰, Karen Wint⁴, John N Wood^4,25.<b>Affiliations</b>¹Medical Genomics, UCL Cancer Institute, London WC1E 6BT, UK.²Institute of Digital Health, University College London, London WC1E 6BT, UK.³Institute for Precision Medicine, University College London, London WC1E 6BT, UK.⁴UK Citizen.⁵Bill Lyons Informatics Centre, UCL Cancer Institute, London WC1E 6BT, UK.⁶Cambridge Precision Medicine Ltd., Future Business Centre, King’s Hedges Road, Cambridge CB4 2HY, UK.⁷MRC Integrative Epidemiology Unit at the University of Bristol, Bristol BS8 2BN, UK.⁸Population Health Sciences, Bristol Medical School, University of Bristol, Bristol BS8 1TH, UK.⁹Head of Pathology, UCL Cancer Institute, London WC1E 6BT, UK.¹⁰Seven Bridges Genomics Inc., 1 Main St, 5th Floor, Suite 500, Cambridge MA 02142, USA.¹¹University College London Hospital, 235 Euston Road, London, NW1 2BU, UK.¹²Division of Surgery and Interventional Science, University College London, London WC1E 6BT, UK.¹³Sharjah Institute of Medical Research, College of Medicine, University of Sharjah, Sharjah, UAE.¹⁴UCL Health Creatives, 30 Guilford Street, London WC1N 1EH, UK.¹⁵Visual Research Centre, Duncan of Jordanstone College of Art and Design, University of Dundee DD1 4DY, UK.¹⁶Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, DE.¹⁷Centre for Health, Law and Emerging Technologies (HeLEX), Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK.¹⁸Melbourne Law School, University of Melbourne, 185 Pelham Street, Carlton Victoria 3053, Australia.¹⁹NIHR Oxford Biomedical Research Centre, The Churchill Hospital, Oxford OX3 7LE, UK.²⁰Division of Biosciences, University College London, London WC1E 6BT, UK.²¹Permanent UK Resident.²²The Royal Australian College of General Practitioners, 100 Wellington Parade, East Melbourne, VIC 3002, AU.²³School of Pharmacy and Biomolecular Sciences, University of Brighton, Brighton, BN2 4GJ, UK.²⁴Arnold & Porter Kaye Scholer LLP, London WC2B 5PQ, UK.²⁵Molecular Nociception Group, WIBR, University College London, London WC1E 6BT, UK.<b>Project coordination</b>Stephan Beck, Olga Chervova, Lucia Conde, José Afonso Guerra-Assunção, Rifat Hamoudi, Paul L Harrison, Javier Herrero, Erica Jones, Jane Kaye, Ismail Moghul, Amy P Webster.<b>IT systems</b>Olga Chervova, Ricarda Gaentzsch, Javier Herrero, Rifat Hamoudi, Vincent Harding, Ismail Moghul, Sevgi Umur, Elizabeth H Williams.<b>Data Analysis</b>Lucia Conde, Simone Ecker, Silvana A Fioramonti, José Afonso Guerra-Assunção, Rifat Hamoudi, Javier Herrero, Emanuele Libertini, Ismail Moghul, Nikolas Pontikos, Kirti Rana, Amy P Webster.<b>Support</b>Alison M Berner, Hannah R Elliott, Adrienne M Flanagan, David Graham, Jana Hofmann, Saif Khan, Polly Kerr, Lauren Marks, Sharmini Rajanayagam, Louise Strom.<b>Citizen science</b>Graham Bignell, Maggie Bond, Martin J Callanan, Manuel Corpas, Deirdre Gribbin, Laura McCormack, Nikolas Pontikos, Momodou Semega-Janneh, Colin P Smith, Karen Wint, John N Wood.<b>Manuscript</b>Stephan Beck wrote the manuscript with contributions from all authors. All authors have approved the manuscript. Corresponding author: Stephan Beck (s.beck@ucl.ac.uk).<b>Links</b>PGP-UK:PGP-UK Data:GenoME app:Global PGP Network:Open Humans:DNA.LandEBI:Ensembl Glossary:Repositive:Seven Bridges Genomics:PGP-UK data in Seven Bridges Genomics cloud:1000 Genomes Project:SNPedia:ExAC:gnomAD:/.GetEvidence:ClinVar:PGP-UK social media:Twitter:Facebook:YouTube:Blog:

: The research conformed to the requirements of the Declaration of Helsinki, UK national laws and to UK regulatory requirements for medical research. All participants were informed, consented, subjected to an online entrance exam and enrolled as described on the PGP-UK sign-up web site (). The study was approved by the UCL Research Ethics Committee (ID Number 4700/001) and is subject to annual reviews and renewals. PGP-UK participants uk35C650, uk33D02F, uk481F67 and uk4CA868 all self-identified and consented for their names, photos, videos and data to be used in the manuscript and GenoME app.

: All authors have approved the manuscript for publication. In addition, PGP-UK participant uk35C650 has self-identified and consented for his photo to be used.

: All authors declare that they have no competing interests.

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