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Article History

Received: 24 March 2021

Accepted: 14 September 2021

First Online: 23 September 2021

Declarations

:

: Written informed consent was obtained from all participants (or parent/ legal guardian) in the 100,000 Genomes Project (IRAS ID 166046; REC reference 14/EE/1112). GW was granted access to the 100,000 Genomes Project research environment by the Genomics England Access Review Committee, as part of the Hearing and Sight, Neurology and Paediatrics Genomics England Clinical Interpretation Partnerships (GeCIPs). Within the 100,000 Genomes Project research environment, research project RR185 ‘Study of cilia and ciliopathy genes across the 100,000 GP cohort’ was registered by GW and approved by Genomics England. This research study received ethical approval from University of Southampton Faculty of Medicine Ethics Committee (ERGO#54400). Further written informed consent was obtained from all participants (or parent/ legal guardian) recruited for PCD diagnostic testing (National Research Ethics Service South Central (A) Committee 07/Q1702/109) and University of Southampton Faculty of Medicine Ethics Committee ERGO #53155.

: Written informed consent was obtained from all participants, or their parents if < 18 years of age, recruited to the 100,000 Genomes Project for data and clinical details to be used for research and publication as part of the informed consent process (IRAS ID 166046; REC reference 14/EE/1112).

: JSL reports grants, personal fees and non-financial support from Circassia. GW is employed by Illumina Inc. Other authors declare no competing interests.