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Whole exome sequencing uncovers genetic syndromes and putative candidate genes underlying orofacial clefts presenting with limb abnormalities in a Sub-Saharan African cohort

Crossref DOI link: https://doi.org/10.1186/s12920-026-02426-2

Published Online: 2026-07-07

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Tackie, Edna

Obiri-Yeboah, Solomon

Mensah, Gideon Okyere

Busch, Tamara D.

Tsri, Bruce

Sabbah, Daniel Kwesi

Asamoah, Christian Opoku

Oti, Alexander Acheampong

Plange-Rhule, Gyikua

Adeyemo, Adebowale A.

Donkor, Peter

Butali, Azeez

Gowans, Lord Jephthah Joojo https://orcid.org/0000-0003-0080-9101
Funding

Funding for this research was provided by:

National Institutes of Health (DE028300)

National Institutes of Health (K43DE029427)

International Association for Dental, Oral and Craniofacial Research (IADR)/Smile Train Cleft Research Award (2023)
License Information

Text and Data Mining valid from 2026-07-07

Accepted Manuscript valid from 2026-07-07
More Information

Article History

Received: 11 December 2025

Accepted: 2 July 2026

First Online: 7 July 2026

Declarations

:

: This study was approved by the Institutional Review Board (IRB) at KATH (KATH-IRB/AP/032/20), Kumasi, Ghana. Written informed consent was obtained from all participating families.

: Not applicable.

: The authors declare no competing interests.

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