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Authors
D’Agostino, Marco
Sileno, Sara
Lulli, Daniela
De Luca, Naomi
Scarponi, Claudia
Teson, Massimo
Torcinaro, Alessio
De Santa, Francesca
Cirielli, Corrado
Furgiuele, Sergio
Morrell, Chris H.
Dellambra, Elena
Odorisio, Teresa
Lakatta, Edward G.
Avitabile, Daniele
Capogrossi, M. C.
Magenta, Alessandra https://orcid.org/0000-0002-9054-337X
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Funding
Funding for this research was provided by:
Ministero della Salute (RF02362708, RC2023)
Intramural resarch program,NIH,NIA
Intramural research program, NIH, NIA
5X1000
Regione Lazio (POR A0375-2020- 36572)
IDI Farmaceutici s.r.l.
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Article History
Received: 22 April 2024
Accepted: 13 December 2024
First Online: 14 February 2025
Declarations
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: The human skin biopsies collection was approved by the Ethics Committee of IDI-IRCCS (Prot. N.29/CE/2018 approved on 09/05/2018). Diabetic biopsies were taken from pts with foot ulcers undergoing major amputation from non-lesional area of limb, control skin biopsies were taken from subjects undergoing saphenectomies. All pts provided written informed consent at enrolment. The study was conducted following the Good Clinical Practice guidelines and according to the declaration of Helsinki. Animal experimentation was approved by the animal welfare organism of IDI-IRCCS and authorized by the Animal Committee of Italian Ministry of Health (protocol n. BBA76.2 approval n. 835/2018-PR expired in March 2023). The BMDM extraction was approved by the animal welfare organism of CNR and authorized by the Animal Committee of Italian Ministry of Health (protocol n.6D050.7 approval n.375/2019 PR expired June 2023).
: Not applicable.
: AM declares that the study has been partially funded by Idi Farmaceutici s.r.l. (2018–2019) which commercializes a topical medicine based on equine catalase. DA is employed by Idi Farmaceutici s.r.l., the remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential competing interests.
