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High-CD14-expressing urothelial cancer cells foster a neutrophil-rich tumor microenvironment that increases the risk of radiation-promoted distant metastasis

Crossref DOI link: https://doi.org/10.1186/s12929-025-01201-2

Published Online: 2026-01-04

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Chiang, Yun

Tsai, Yu-Chieh

Wang, Chung-Chieh

Hsueh, Fu-Jen

Huang, Chao-Yuan

Chen, Chung-Hsin

Pu, Yeong-Shiau

Chueh, Shih-Chieh

Tsai, Xavier Cheng-Hong

Cheng, Jason Chia-Hsien
Funding

Funding for this research was provided by:

National Science and Technology Council (MOST 110-2314-B-002-147-MY3)

National Science and Technology Council (MOST 112-2314-B-002-116-MY3)

National Taiwan University Hospital (NTUH 112-O0005)

National Taiwan University Cancer Center (NTUCCS 113-08)
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Text and Data Mining valid from 2026-01-04

Version of Record valid from 2026-01-04
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Article History

Received: 6 June 2025

Accepted: 14 November 2025

First Online: 4 January 2026

Declarations

:

: All experimental procedures involving these mice were conducted in accordance with protocols approved by the National Taiwan University Institutional Animal Care and Use Committee.

: Not applicable.

: The authors declare no competing interests.

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