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Article History

Received: 29 January 2019

Accepted: 24 April 2019

First Online: 22 May 2019

Ethics approval

: Animal welfareThe UK Home Office controls scientific procedures on animals in the UK and does so by issue of licences under the Animals (Scientific Procedures) Act 1986. The regulations conform to EU Directive 2010/63/EU and achieve the standard of care required by the US Department of Health and Human Services’ Guide for the Care and Use of Laboratory.The CSL/Zoetis Animal Ethics Committee, the Albany Medical College IACUC and the University of Melbourne Animal Ethics Committee approved all mouse related procedures and protocols.

: All authors read and approved the final manuscript.

: CV, KS and UB declare the submission of patent WO2015/150510, pending to CSL Behring AG, PARI Pharma GmBH, Hanover Medical School (University of Hannover). Other authors declare that they have no competing interests.

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