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Article History

Received: 12 March 2019

Accepted: 13 May 2019

First Online: 22 May 2019

Ethics approval and consent to participate

: All analyses were performed after obtaining approval from the Institutional Review Board of the University of Alabama at Birmingham.

: Not applicable

: M-LNM reports grants from National Institutes of Health, other from Parker B. Francis Foundation, during the conduct of the study and personal fees from Pfizer, outside the submitted work.EFMW has received personal fees from Nycomed, Boehringer, AstraZeneca, GSK, Novartis and Chiesi. EFMW has received grants from AstraZeneca and GSK.ER has no competing interests.RC has received personal fees from GSK, Boehringer Ingelheim, Astra Zeneca, Genentech and Regeneron.SIR reports other from AstraZeneca, outside the submitted work. S.I.R. is employed by AstraZeneca.DAL reports grants, personal fees and non-financial support from GSK during the conduct of the study and personal fees from Griffols, outside the submitted work.MB has no competing interests.BC reports personal fees and other from Astra Zeneca, personal fees from GlaxoSmithKline, personal fees from Boehringer Ingelheim, personal fees from Novartis, personal fees from Sanofi Aventis and personal fess form Menarini other from outside the submitted work.AA reports personal fees from GSK, during the conduct of the study.RT-S is an employee and shareholder of GSK, the ECLIPSE study sponsor.CPH reports personal fees from Mylan, personal fees from AstraZeneca, personal fees from Concert Pharmaceuticals, personal fees from 23andMe, grants from Novartis, grants from Boehringer-Ingelheim, grants from NHLBI, outside the submitted work.MD reports grants from Department of Defense, personal fees and other from Boehringer Ingelheim, personal fees and other from GSK, other from Novartis, personal fees and other from AstraZeneca, other from Yungjin, personal fees and other from PneumRx/BTG, other from Pulmonx, personal fees from Genentech, personal fees and other from Boston Scientific, personal fees from Quark Pharmaceuticals, grants from NIH, outside the submitted work.EKS reports grants, personal fees and other from GSK, during the conduct of the study; personal fees from Novartis, outside the submitted work.

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