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Article History

Received: 1 May 2019

Accepted: 3 September 2019

First Online: 12 September 2019

Ethics approval and consent to participate

: The required statement is in the methods section and detailed information about the research/ethics review committees which reviewed the study is provided in the Supplement (it is 5 pages in length).

: Not applicable.

: RJW has conducted clinical research for Gilead and serves as a consultant with total remuneration < $10,000 annually; he holds no equity. SR received remunerations for lectures and/or consultancy from Abbott, Actelion, Arena, Bayer, BMS, MSD, Novartis, Pfizer, and United Therapeutics; his institution received research grants from Actelion, Bayer, Novartis, and United Therapeutics. AEF received remunerations for lectures and/or consultancy from United Therapeutics, Actelion, Gilead Sciences, for participation as study Endpoint Adjudication or Safety Committees from United Therapeutics, & Complexa. EG received speaker honoraria/consultancy fees from Actelion, Bayer/MSD, Orpha Swiss GmbH, Medscape, his institution received research grants from Actelion, Bayer/MSD, GSK, Bial, United Therapeutics, Novartis, Bellerophon, OMT, Pfizer, Reata. MMC received remunerations for lectures and/or consultancy totaling < $10,000 annually from Actelion, Bayer, Gilead, United Therapeutics, Reata, Arena, Medscape, Express Scripts, and Phase Bio; his institution received research grants from Actelion, Bayer, Gilead, Medtronic, Eiger, Liquidia, Arena, and Phase Bio. RJO has received speaker/consulting honoraria from Actelion, Arena, Gilead, Medscape, Medtronic, Reata, and United Therapeutics; his institution received research grants from AAdi, Actelion, Arena, Gilead, GSK, Liquidia, Reata, and United Therapeutics. JL was an employee of GSK during the conduct of the study and the preparation of the manuscript. CB is an employee of Gilead with equity interest.