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Article History

Received: 23 March 2020

Accepted: 1 April 2020

First Online: 9 September 2020

Ethics approval and consent to participate

: The study protocol was approved by an Independent Ethics Committee (NRES Committee – Cambridgeshire and Hertfordshire, Health Research Authority, Nottingham, UK; Reference No 15/EE/0329; see Additional file InternalRef removed) and the UK Medicines and Healthcare Products Regulatory Agency. The informed consent form was also reviewed by the Independent Ethics Committee. The study was performed in accordance with the Declaration of Helsinki and the International Conference on Harmonization/Good Clinical Practice guidelines. All patients provided written, informed consent before enrolment in the study.

: Not applicable.

: D. S. has received sponsorship to attend international meetings, honoraria for lecturing or attending advisory boards, and research grants from various pharmaceutical companies including Apellis, AstraZeneca, Boehringer Ingelheim, Chiesi, Cipla, Genentech, GlaxoSmithKline, Glenmark, Johnson and Johnson, Menarini, Mundipharma, Novartis, Peptinnovate, Pfizer, Pulmatrix, Skypharma, Teva, Therevance, and Verona. V. B., C. A., U. W. H., L. J., B. S., A. L., and I. P. are employees of AstraZeneca and may own stock or stock options. C. V. and A. A. were employees of AstraZeneca at the time the study was conducted. C. V. is a current employee of PAREXEL. A. A. is a current employee of Eloxx Pharmaceuticals.