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Article History

Received: 18 December 2024

Accepted: 12 February 2025

First Online: 28 February 2025

Declarations

:

: Ethics approval was obtained from the Isle of Wight Local Research Ethics Committee at recruitment of this birth cohort born on the Isle of Wight, United Kingdom, between January 1989 and February 1990. Parents and children also consented for their data to be used at a later stage to identify asthma. Written informed consent was obtained from all children and parents before they participated in the study. For the F2 generation, we received ethics approval from the Isle of Wight, Portsmouth, and SE Hampshire Local Research Ethics Committee (Study Title: A study of epigenetic driven immunological changes in the development of Asthma and Allergy in infancy). Research Ethics Committee Reference Number: 09/H0504/129; Protocol number: 1; 4 December 2009. The latest renewal was on 14 October 2021, by the NRES Committee South Central—Hampshire B (09/H0504/129). At the University of Memphis, the Institutional Review Board approved the investigation (#2423).

: Not applicable.

: Written informed consents were obtained from the parents until age 10 and at 18 and 26 years from the participants at each follow-up. The ethical principles for medical research involving humans with identifiable data followed the Declaration of Helsinki. For participants assessed by phone interview, consent was documented on the consent form with the name of the person giving consent, and the name and signature of the person taking the form were recorded.

: Not applicable.

: The authors declare no competing interests.