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Fibulin 5 mediates pulmonary artery smooth muscle cell dysfunction and vascular remodelling in congenital heart disease associated pulmonary arterial hypertension via TGF-β1/PI3K/AKT signalling

Crossref DOI link: https://doi.org/10.1186/s12931-025-03361-z

Published Online: 2025-09-29

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Zhou, Jing-Jing

Qiao, En

He, Zhi-Yu

Yang, Yi-Cheng

Qian, Yu-Ling
Funding

Funding for this research was provided by:

National Natural Science Foundation of China (82200335, 82300408)

China Postdoctoral Science Foundation (2024M762875)
License Information

Text and Data Mining valid from 2025-09-29

Version of Record valid from 2025-09-29
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Article History

Received: 27 June 2025

Accepted: 9 September 2025

First Online: 29 September 2025

Declarations

:

: The clinical data analysis was approved by the Ethics Committee of Fuwai Hospital. All animal experiments were authorized by the Institutional Animal Care and Use Committee of Fuwai Hospital.

: Not applicable.

: The authors declare no competing interests.

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