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Authors
Haastrup, Adeyeye I.
Roberts, Justin T.
Gandotra, Sheetal
Hartsell, Emily M.
Daly, Grant T.
Pastukh, Viktor M.
Purcell, Lina D.
Benton, Ryan G.
Files, D. Clark
Stevens, Troy
Gillespie, Mark N.
Morris, Peter E.
Langley, Raymond J.
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Funding
Funding for this research was provided by:
Frederick P. Whiddon College of Medicine (Dean's Predoctoral Fellowship Award (2024 -2026))
USA Center for Lung Biology (Gary and Susan Godwin Emerging Scholars Endowed Award)
American Thoracic Society (Young Investigators Award)
National Institutes of Health (1UL1TR001417)
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Article History
Received: 17 August 2025
Accepted: 6 November 2025
First Online: 21 November 2025
Declarations
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: This retrospective study involved ARF patients enrolled in the Standardized Rehabilitation for ICU Patients with Acute Respiratory Failure clinical trial at Wake Forest Baptist Medical Center in North Carolina (ClinicalTrials.gov Identifier, NCT00976833; registration date, 2009–09-11). The Wake Forest IRB approval is in accordance with the Declaration of Helsinki. Institutional review board approval was obtained, and informed consent was provided by patients or their legal representatives.
: Not applicable.
: We developed a predictive model using a Bayesian framework that incorporates seven key metabolite biomarkers to estimate future physical function in critically ill patients following hospital discharge. To support future clinical translation, a provisional patent application has been filed to secure intellectual property rights for this biomarker-based prediction method.
