Crossmark

Long-acting β2 agonist (LABA) with a long-acting muscarinic receptor antagonist (LAMA) promotes human airway smooth muscle (HASM) relaxation and circumvents β2 adrenergic receptor tachyphylaxis

Crossref DOI link: https://doi.org/10.1186/s12931-025-03427-y

Published Online: 2025-12-03

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Jude, Joseph

Karmacharya, Nikhil

Sherpa, Rinzhin T.

O’Riordan, Thomas G.

Koziol-White, Cynthia J.

Panettieri, Reynold A.
Funding

Funding for this research was provided by:

National Heart, Lung, and Blood Institute

GlaxoSmithKline
License Information

Text and Data Mining valid from 2025-12-03

Version of Record valid from 2026-01-07
More Information

Article History

Received: 23 September 2025

Accepted: 9 November 2025

First Online: 3 December 2025

Declarations

:

: Not applicable.

: Not applicable.

: Thomas G. O’Riordan, MD was an employee of GlaxoSmithKline (GSK) during the part of the study.

Document is current

Any future updates will be listed below