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Single-cell RNA sequencing elucidates potential mechanisms of endothelial cells in lung region-specific repair and remodeling in combined pulmonary fibrosis and emphysema

Crossref DOI link: https://doi.org/10.1186/s12931-025-03460-x

Published Online: 2026-01-06

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Hu, Huiyuan

Guo, Zhuangjie

Zhang, Jin

Gao, Yidan

Jiang, Xuehan

Yang, Haoshuai

Hu, Yufei

Zhang, Hong

Song, Wanlu

Liang, Chaoyang

Yang, Peiran

Wang, Chen
Funding

Funding for this research was provided by:

Noncommunicable Chronic Diseases-National Science and Technology Major Project (2024ZD0528700)

National Natural Science Foundation of China (82270062)

Beijing Municipal Natural Science Foundation (7242096)

Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences (2021-I2M-1-001)

Non-Profit Central Research Institute Fund of the Chinese Academy of Medical Sciences (2021-RC310-016)

the State Key Laboratory Special Fund (2060204)
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Text and Data Mining valid from 2026-01-06

Version of Record valid from 2026-02-03
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Article History

Received: 8 September 2025

Accepted: 13 December 2025

First Online: 6 January 2026

Declarations

:

: The study protocol involving the collection of human specimens was approved by the Clinical Research Ethics Committee of China-Japan Friendship Hospital (Approval No. 2024-KY-039). All procedures performed in this study were in accordance with the ethical standards of the Declaration of Helsinki. Written informed consent was obtained from all participants prior to their enrollment.

: Not applicable.

: The authors declare no competing interests.

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