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SPECT as a translational non-invasive method to assess occupancy of the tissue transglutaminase-2 by zampilimab in the mouse lung

Published Online: 2026-02-12

Authors

Bellaye, Pierre-Simon

Ferrini, Erica

Claron, Michaël

Dias, Alexandre

Bonfini, Costanza

Villetti, Gino

Capelli, Anna Maria

Johnson, Timothy

Collin, Bertrand https://orcid.org/0000-0002-0360-0664
Stellari, Franco Fabio https://orcid.org/0000-0002-8855-7297
Funding

Funding for this research was provided by:

Chiesi Farmaceutici

ANTHEM (AdvaNced Technologies for Human-centrEd Medicine), Spoke 3
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Text and Data Mining valid from 2026-02-12

Version of Record valid from 2026-03-18
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Article History

Received: 4 December 2025

Accepted: 4 February 2026

First Online: 12 February 2026

Declarations

:

: All animal studies were conducted at the imaging platform IMATHERA (BioSanD – UMS INSERM 58) of the CGFL, DIJON, in accordance with the legislation on the use of laboratory animals (directive 2010/63/EU) and were approved by the accredited ethical committee (C2ea Grand Campus n°105) and the French Ministries of Research and Agriculture (project #47968, and #34338).

: Not applicable.

: The authors declare no competing interests.

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