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Article History

Received: 15 September 2020

Accepted: 17 December 2020

First Online: 7 January 2021

Ethics approval and consent to participate

: This is a subsequent analysis of a multicenter clinical trial. All sites required local ethics committee approval prior to study initiation and all participating patients provided informed, written consent.

: Not applicable.

: SJN reports research grants from AstraZeneca, Amgen, Anthera, Eli Lilly, Esperion, Novartis, Cerenis, The Medicines Company, Resverlogix, InfraReDx, Roche, Sanofi-Regeneron and LipoScience and honoraria from AstraZeneca, Akcea, Eli Lilly, Anthera, Omthera, Merck, Takeda, Resverlogix, Sanofi-Regeneron, CSL Behring, Esperion, Boehringer Ingelheim. GGS reports grants to his institution from Resverlogix, Roche, Sanofi and The Medicines Company. GGS also has a pending patent US 62/806,313 "Methods for Reducing Cardiovascular Risk" assigned in full to the University of Colorado. KAB reports research grants from Resverlogix, The Medicines Company, GlaxoSmithKline, Pfizer, BioCardia, Amgen and Cytokinetics. HNG reports honoraria from Resverlogix. JOJ, EK, NW and MS are employees of Resverlogix. KK-Z reports honoraria from Abbott, Abbvie, Alexion, Amgen, AstraZeneca, Aveo, Chugai, DaVita, Fresenius Medical Services, Genentech, Haymarket, Hospira, Kabi, Keryx, Novartis, Pfizer, Relypsa, Resverlogix, Sandoz, Sanofi, Vifor, ZS-Pharma, UpToDate, Baxter, Dr Schaer, Amag Pharma and grants from Shire, PCORI and NIH. PPT reports honoraria from Resverlogix, Amarin, Amgen, Kowa, Merck, Novo-Nordisk, Regeneron, Sanofi, Theravance. KKR reports honoraria from Resverlogix, Aegerion, Amgen, Pfizer, AstraZeneca, Cerenis, Akcea, The Medicines Company, Kowa, Novartis, Cipla, Eli Lilly, Algorithm, Takeda, Boehringer Ingelheim, Abbvie, Silence Therapeutics, Dr Reddys, Bayer, Daiichi Sankyo, Esperion, Zuelling Pharma, Sanofi-Regeneron and Merck and grants from Sanofi-Regeneron and Merck.