Document is current

Article History

Received: 4 July 2022

Accepted: 1 September 2022

First Online: 23 September 2022

Declarations

:

: The CANVAS trial was conducted in accordance with the Declaration of Helsinki (clinicaltrials.gov: NCT01032629). The study protocol was approved by ethics committee at each participating site. All participants provided written informed consent.

: The manuscript was approved by all authors for publication.

: S.C.T, N.J., and P.V. report no conflicts of interest. S.G.C has received consulting fees from Goldfinch Bio, Janssen Pharmaceuticals and is on the scientific advisory board of pulseData LLC. C.A.is an employee of the George Institute for Global Health and has received honoraria from Amgen. J.S. reports stock ownership in companies providing services to Itrim, Amgen, Janssen, Novo Nordisk, Eli Lilly, Boehringer, Bayer, Pfizer, Takeda and AstraZeneca, outside the submitted work. C.A. is supported by an NSW Health EMCR Fellowship and an NHMRC/MRFF Priority Investigator Grant. She is an employee of the George Institute for Global Health. B.N. was a member of the CANVAS study steering committees and his institution received grant funding support for those trials as well as funding for consultancies done for Janssen, Merck, Mundi Pharma, and Mitsubishi Tanabe. V.P. is employed by UNSW Sydney and the Royal North Shore Hospital, and serves as a Board Director for St.Vincents Health Australia, George Clinical and several Medical Research Institutes. He has led or served on the Steering Committees of trials funded by Abbvie, Bayer, GSK, Boehringer Ingelheim, Eli Lilly, Gilead, Janssen, Novartis, Novo Nordisk, Otsuka, Pfizer, Retrophin/Travere, and Tricida. V.P. also reports having receiving honoraria for scientific presentations and/or advisory board attendance from Abbvie, Amgen, Astra Zeneca, Bayer, Baxter, Boehringer Ingelheim, Chinook, Durect, Eli Lilly, Gilead, GSK, Janssen, Merck, Mitsubishi Tanabe, Mundipharma, Novartis, Novo Nordisk, Pharmalink, Pfizer, Reata, Relypsa, Roche, Sanofi, and Servier. K.W. M. was a co-chair of the CANVAS steering committee. He has received research support from Afferent, Amgen, Apple Inc., AstraZeneca, Cardiva Medical Inc., Daiichi Sankyo, Ferring, Google (Verily), Johnson & Johnson, Luitpold, Medtronic, Merck, National Institutes of Health (NIH), Novartis, Sanofi, St. Jude,, and Tenax, has served as a consultant (speaker fees for continuing medical education events only) for Abbott, Ablynx, AstraZeneca, Baim Institute, Boehringer Ingelheim, Bristol Myers Squibb, Elsevier, GlaxoSmithKline, Johnson & Johnson, MedErgy, Medscape, Mitsubishi Tanabe, Myokardia, NIH, Novartis, Novo Nordisk, Portola, Radiometer, Regeneron, Springer Publishing, and University of California, San Francisco, and has received personal fees from Abbott, Anthos, CSL Behring, Intermountain Health, Mount Sinai, Mundi Pharma, SmartMedics, and Theravance, outside the submitted work. H.J.L.H. is a consultant for Abbvie, AstraZeneca, Boehringer Ingelheim, Bayer, CSL-Behring, Chinook, Dimerix, Eli-Lilly, Gilead, GoldFinch Janssen, Merck, Mitsubishi Tanabe MundiPharma Novartis, NovoNordisk and Travere Therapeutics and received research support from AstraZeneca, Boehringer Ingelheim, Janssen, and NovoNordisk (payments to his employer).