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Temporal and subgroup disparities in mediation effects on cardiovascular outcomes with liraglutide and semaglutide: a post-hoc analysis of LEADER and SUSTAIN-6 trials

Crossref DOI link: https://doi.org/10.1186/s12933-025-03007-w

Published Online: 2025-11-24

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Peng, Zi-Yang

Lee, Yu-Hsuan

Ou, Huang-Tz

Kuo, Shihchen
Funding

Funding for this research was provided by:

National Science and Technology Council in Taiwan (grant NSTC 112-2628-B-006-008-MY3)
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Text and Data Mining valid from 2025-11-24

Version of Record valid from 2025-11-24
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Article History

Received: 5 August 2025

Accepted: 4 November 2025

First Online: 24 November 2025

Declarations

:

: To comply with the Declaration of Helsinki, both trials adhered to the policy of the institutional review board or ethics committee at the corresponding study site, with written informed consent provided to the trial participants at enrollment.

: Not applicable.

: The authors declare no competing interests.

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