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Authors
Holm, Peter C. https://orcid.org/0000-0003-3363-5611
Haue, Amalie D. https://orcid.org/0000-0001-7656-7976
Westergaard, David https://orcid.org/0000-0003-0128-8432
Röder, Timo https://orcid.org/0000-0001-6841-4056
Banasik, Karina https://orcid.org/0000-0003-2489-2499
Tragante, Vinicius
Johansen, Christian H. https://orcid.org/0000-0001-8665-2111
Christensen, Alex H.
Thomas, Laurent
Nøst, Therese H.
Skogholt, Anne-Heidi https://orcid.org/0000-0001-7466-0405
Iversen, Kasper K. https://orcid.org/0000-0003-0504-8487
Pedersen, Frants https://orcid.org/0000-0002-0071-3209
Høfsten, Dan E. https://orcid.org/0000-0002-7609-4141
Pedersen, Ole B. https://orcid.org/0000-0003-2312-5976
Ostrowski, Sisse Rye https://orcid.org/0000-0001-5288-3851
Ullum, Henrik https://orcid.org/0000-0001-7306-9058
Svendsen, Mette N. https://orcid.org/0000-0002-4777-4973
Gjødsbøl, Iben M. https://orcid.org/0000-0003-3938-5211
Gudnason, Thorarinn https://orcid.org/0000-0001-6440-3712
Guðbjartsson, Daníel F. https://orcid.org/0000-0002-5222-9857
Helgadottir, Anna https://orcid.org/0000-0002-1806-2467
Hveem, Kristian https://orcid.org/0000-0001-8157-9744
Køber, Lars V. https://orcid.org/0000-0002-6635-1466
Holm, Hilma https://orcid.org/0000-0002-9517-6636
Stefansson, Kari https://orcid.org/0000-0003-1676-864X
Brunak, Søren https://orcid.org/0000-0003-0316-5866
Bundgaard, Henning https://orcid.org/0000-0002-0563-7049
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Funding
Funding for this research was provided by:
Copenhagen University
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Article History
Received: 3 September 2025
Accepted: 5 January 2026
First Online: 28 January 2026
Declarations
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: The study was approved by The National Ethics Committee (1708829, ‘Genetics of CVD’—a genome-wide association study on repository samples from CHB), The Danish Data ProtectionAgency (ref: 514-0255/18-3000, 514-0254/18-3000, SUND-2016-50), The Danish Health DataAuthority (ref: FSEID-00003724 and FSEID-00003092), and The Danish Patient Safety Authority (3-3013-1731/1/). The National Danish Ethics Committee have waived the need for informed consent due to the societal value of the study. Danish personal identifiers were pseudonymised prior to any analysis.The validation part of the study was approved by the Data Protection Authority of Iceland and the National Bioethics Committee of Iceland (VSN-15-114). Icelandic participants that donated biological samples provided informed consent. Personal identities of the participants were encrypted with a third-party system provided by the Data Protection Authority of Iceland.Study design, methods, and results were reported in agreement with the TRIPOD statement [ , ] and following the STROBE recommendations [ ]. A filled-out TRIPOD checklist is included in the Supplementary Information document.
: Lars V. Køber reports speakers honorarium from AstraZeneca, Boehringer, Novartis and Novo Nordisk. Søren Brunak reports ownerships in Hoba Therapeutics, Novo Nordisk, Eli Lilly & Co., andLundbeck, and has received lecture fees from MDS, Bayer, LEO Pharma, Roche and Astellas. Henning Bundgaard reports ownership in Novo Nordisk and has received lecture fees from Amgen, BMS, MSD and Sanofi. The following co-authors are or were employed by deCODE genetics/Amgen, Inc: Vinicius Tragante, Daníel F. Guðbjartsson, Anna Helgadottir, Hilma Holm, and Kari Stefansson. The rest of the authors declare no competing interests.
