Shi, Kaijia https://orcid.org/0000-0001-9286-2879
Fan, Yonghao https://orcid.org/0009-0008-2538-2777
Chen, Xu https://orcid.org/0009-0007-3354-6578
Shen, Zhihua https://orcid.org/0000-0002-0451-8873
Guo, Junli https://orcid.org/0000-0002-9740-9819
Funding for this research was provided by:
The Fifth Affiliated Hospital of Wenzhou Medical University Postdoctoral Research Start-up Project (20255453)
National Key R&D Program of China (2024YFA1802300)
National Natural Science Foundation of China (U220A20270)
National Natural Science Foundation of China (82560052, 82260083, 82060053)
Academic Enhancement Support Program of Hainan Medical University (XSTS2025043)
Hainan Province Science and Technology Special Fund (ZDYF2026SHFZ040, ZDYF2022SHFZ038, ZDYF2020122)
Article History
Received: 19 July 2026
Accepted: 21 September 2026
First Online: 30 September 2026
Declarations
Ethics approval and consent to participate: Not applicable.
Consent for publication: Not applicable.
Declaration of generative AI and AI-assisted technologies in the writing process: During the preparation of this work, the authors used DeepSeek to improve the readability and language of the manuscript. After using this tool, the authors reviewed and edited the content as needed and take full responsibility for the final published version. The figures were prepared with the assistance of BioRender.com.
Competing interests: The authors declare no competing interests.