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Article History

Received: 11 February 2019

Accepted: 7 May 2019

First Online: 17 May 2019

Ethics approval and consent to participate

: Informed consent was obtained from all patients and ethics approval was obtained from Committee on the Ethics of the First Affiliated Hospital of Guangzhou Medical University (Permit number: 2012–41). The animal experiments were carried out in strict accordance with the recommendations in the Guide for the Care and Use of Laboratory Animals of Guangzhou Medical University. Animals were purchased from Animal experimental center, Guangdong, China. The protocol was approved by the Committee on the Ethics of the First Affiliated Hospital of Guangzhou Medical University (Permit number: SYXK 2016-0168). All surgery was performed under sodium pentobarbital anesthesia, and all efforts were made to minimize suffering.

: Not applicable.

: The authors declare that they have no competing interests.