Iwama, Takuya
Fujiya, Mikihiro http://orcid.org/0000-0002-4321-7774
Konishi, Hiroaki
Tanaka, Hiroki
Murakami, Yuki
Kunogi, Takehito
Sasaki, Takahiro
Takahashi, Keitaro
Ando, Katsuyoshi
Ueno, Nobuhiro
Kashima, Shin
Moriichi, Kentaro
Tanabe, Hiroki
Okumura, Toshikatsu
Funding for this research was provided by:
Yakult Honsha
EA Pharma Co., Ltd.
Nippon Kayaku Co., Ltd
Novartis Pharmaceuticals Corporation
Boehringer Ingelheim
Technical Informaition Insititute Co., Ltd
Pfizer Japan
Takeda Pharmaceutical Company
Daiichi-Sankyo
Shionogi
Olympus
Janssen Pharmaceuticals
KYORIN Pharmaceutical Co., Ltd.
Taisho Toyama Pharmaceutical Company
AstraZeneca
Tomakomai Minpo Co.,Ltd
Meiji Seika Pharma
Mochida Pharmaceutical Company
Astellas Pharma
Mitsubishi Tanabe Pharma Corporation
Baxter International
Bristol-Myers Squibb
Chugai Pharmaceutical
MSD K.K.
Otsuka Pharmaceutical
Kyowa Hakko Kirin
Taiho Pharmaceutical
ZERIA Pharmaceutical Co.,Ltd.
Alexion Pharmaceuticals
Ajinomoto Pharmaceuticals
Asahi Kasei Pharma Corporation
Sapporo Breweries LTD
Eisai
GlaxoSmithKline
AbbVie
Dainippon Sumitomo Pharma
ASKA Pharmaceutical Co., Ltd.
Boston Scientific Corporation
Kamui Pharma. Inc
Japanese Grants-in-Aid for Scientific Research (18K07927)
Japanese Grants-in-Aid for Scientific Research (19K16484)
Japanese Grants-in-Aid for Scientific Research (17K08779)
Japanese Grants-in-Aid for Scientific Research (19K17419)
Japanese Grants-in-Aid for Scientific Research (17K15911)
Development and Intractable Disease Health and Labour Sciences Research Grants from the Ministry of Health, Labour and Welfare
a patent Intestinal Protectant (JP 5660508)
a patent Intestinal Protectant (EP 2559437)
Translational Research Network Program of Japan Agency for Medical Research and Development (TR-A407)
Takeda Science Foundation
Japanese Grants-in-Aid for Scientific Research
Article History
Received: 11 March 2020
Accepted: 19 December 2020
First Online: 6 January 2021
Ethics approval and consent to participate
: All the procedures in this study involving human participants were carried out in accordance with the 1964 Helsinki declaration and its subsequent amendments. The plan was approved by the Ethics Committee of Asahikawa Medical University. The study obtained the informed consent of all participants. In addition, the care and use of experimental animals comply with principles and standards set forth in the Principles for Use of Animals.
: All authors approved the publication of this manuscript.
: The authors declare that they have no competing interests.