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Article History

Received: 18 May 2018

Accepted: 1 August 2018

First Online: 21 August 2018

Ethics approval and consent to participate

: Tissue microarrays (TMA) of ESCC specimens were obtained from Shanghai Outdo Biotech Co., Ltd. (SOBC), with the approval of the Institutional Review Board. The ESCC tissues and matched adjacent normal tissues and the serum samples of ESCC patients and health persons used for real time PCR assay were histopathologically and clinically diagnosed at Beijing Cancer Hospital and the Cancer Institute and Hospital, Chinese Academic of Medical Sciences & Peking Union Medical College (Additional file : Table S17). Written informed consent was obtained from all patients prior to the study. The use of the clinical specimens for research purposes was approved by the Institutional Research Ethics Committee.All animal care and procedures were in accordance with national and institutional policies for animal health and well-being. Mouse experimentations were approved by Cancer Institute and Hospital, Chinese Academic of Medical Sciences & Peking Union Medical College Animal Care and Use Committee. All mouse surgery was performed under anesthesia, and all efforts were made to minimize suffering of animals.

: Not applicable

: The authors declare that they have no competing interests.

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