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Article History

Received: 14 June 2021

Accepted: 30 August 2021

First Online: 20 October 2021

Declarations

:

: All animal experiments were approved by the “Ministère de l’Enseignement Supérieur, de la Recherche et de l’Innovation (MESRI)” (authorization numbers 2,016,072,015,478,042; 2,015,110,618,597,936 and 2,015,070,315,335,217), and were carried out in accordance with the approved protocols. Patient samples (tumor tissue and plasma) from the UroCCR cohort were used with associated clinical data (ExternalRef removed, NCT03293563). Eligible patients for SUVEGIL and TORAVA trials were at least 18 years of age and had metastatic ccRCC histologically confirmed, with the presence of measurable disease according to Response Evaluation Criteria in Solid Tumors v1.1. These studies were approved by the ethic committee at each participating center and run in agreement with the International Conference on Harmonization of Good Clinical Practice Guideline.

: The authors approve the publication of this manuscript.

: There is no competing interest to declare. Patents with regard to this article: 1) New gene signatures predicting survival time in patients suffering from renal cell carcinoma, EP21183633.3; July 5, 2021, 2) New biomarkers and targets in renal cell carcinoma, EP19305252.9, March 5th, 2019.