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Article History

Received: 27 February 2023

Accepted: 27 June 2023

First Online: 13 July 2023

Declarations

:

: Human studies were conducted in accordance with the Declaration of Helsinki, under an approved protocol of the Institutional Review Boards of the three participating hospitals (2020/122-ONC-DEX). Samples were de-identified for patient confidentiality and informed written consent was obtained from all subjects.All animal experiments were approved by Astra Zeneca Oncology Animal Welfare Committee. Experiments performed in Xenopat were additionally approved by the Ethical Committee of Animal Experimentation of the Parc Científic de Barcelona (PCB), following the Astra Zeneca Oncology Animal Welfare Criteria and the guidance of the Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC, Unit 1155).

: Not applicable.

: I.S. has received fees for consultancy or advisory roles from Roche, Novartis, Boehringer Ingelheim and Takeda. N.R. has received fees for consultancy or advisory roles from Merck Sharp & Dohme Corp, Bristol-Myers Squibb and Pfizer. A.A.H. has received fees for consultancy or advisory roles from Bristol-Myers Squibb, Roche, Merck Sharp & Dohme Corp and Lilly. J.T., S.T., R.W., N.F., G.G., M.X., P.S., J.S., G.F., A.G., U.P. and J.U. are current or former AstraZeneca employees and shareholders. M.A.M.V. has received research funding from Astra Zeneca, In3Bio and Merck Healthcare KGaA. The rest of the authors declare no competing interests.