Vasseur, Damien
Bigot, Ludovic
Beshiri, Kristi
Flórez-Arango, Juan
Facchinetti, Francesco
Hollebecque, Antoine
Tselikas, Lambros
Aldea, Mihaela
Blanc-Durand, Felix
Gazzah, Anas
Planchard, David
Lacroix, Ludovic
Pata-Merci, Noémie
Nobre, Catline
Da Silva, Alice
Nicotra, Claudio
Ngo-Camus, Maud
Braye, Floriane
Nikolaev, Sergey I.
Michiels, Stefan
Jules-Clement, Gérôme
Olaussen, Ken André
André, Fabrice
Scoazec, Jean-Yves
Barlesi, Fabrice
Ponce, Santiago
Soria, Jean-Charles
Besse, Benjamin
Loriot, Yohann
Friboulet, Luc
Article History
Received: 8 July 2024
Accepted: 20 September 2024
First Online: 4 October 2024
Declarations
:
: The MATCH-R clinical trial (NCT02517892) was a monocentric, prospective study conducted between 2015 and 2022 and led by Gustave Roussy. This protocol was approved by the CPP (“Comité de protection des personnes”) and by the ANSM (“Agence nationale de sécurité du médicament et des produits de santé”) and adhered to the principles in the Guideline for Good Clinical Practice and the Declaration of Helsinki. Each individual genomic report was reviewed and discussed within a multidisciplinary internal review board. All animal procedures and studies were performed in accordance with the approved guidelines for animal experimentation by the ethics committee at University Paris Saclay (CEEA 26, Project 2014_055_2790) following the regulations set by the European Union. The animals were housed in pathogen-free conditions and provided unlimited food and water access.Patients able to comply with the protocol were fully informed and signed an informed consent. Written informed consent was obtained from all patients included in this study.
: Not applicable.
: D. Vasseur: speaker for Roche and Astra Zeneca JC. Soria: Full time employee of Amgen. Share-holder of Amgen. LF: Research funding from Debiopharm, Incyte, Relay Therapeutics, Sanofi and Nuvalent. F. Facchinetti : personal fees from BeiGene outside the submitted work. Y. Loriot : personal fees, nonfinancial support, and other support from Janssen during the conduct of the study, as well as personal fees, nonfinancial support, and other support from MSD, Pfizer, Merck KGaA, Astellas, Gilead, Bristol Myers Squibb, and Roche, nonfinancial support and other support from Incyte, other support from Exelixis, and personal fees and other support from Taiho outside the submitted work. S. Michiels : personal fees from DSMB or scientific committee study membership for Kedrion, Biophytis, Servier, IQVIA, Yuhan, and Roche outside the submitted work. L. Tselikas : personal fees from Incyte during the conduct of the study, as well as personal fees from GE Healthcare, Quantum Surgical, and Boston Scientific outside the submitted work. B. Besse : other support from AbbVie, BioNTech SE, Bristol Myers Squibb, Chugai Pharmaceutical, CureVac AG, Daiichi Sankyo, F. Hoffmann-La Roche Ltd, PharmaMar, Regeneron, Sanofi-Aventis, and Turning Point Therapeutics, other support from AbbVie, Eli Lilly and Company, Ellipses Pharma Ltd, F.Hoffmann-La Roche Ltd, Genmab, Immunocore, Janssen, MSD, Ose Immunotherapeutics, Owkin, and Taiho oncology, other support from AstraZeneca, BeiGene, Genmab A/S, GlaxoSmithKline, Janssen, MSD, Ose Immunotherapeutics, PharmaMar, Roche-Genentech, Sanofi, and Takeda, and other support from AbbVie, AstraZeneca, Chugai Pharmaceutical, Daichii Sankyo, Hedera Dx, Janssen, MSD, Roche, Sanofi-Aventis, and Springer Healthcare Ltd during the conduct of the study. F. André : grants from AstraZeneca, Guardant Health, Novartis, Owkin, Pfizer, Eli Lilly and Company, Roche, and Daiichi Sankyo, other support from Boston Pharmaceutics, Gilead, and Servier, and grants and other support from N-Power medicine outside the submitted work. A. Hollebecque : personal fees and nonfinancial support from Amgen, personal fees from Basilea, Bristol Myers and Squibb, Servier, Relay Therapeutics, Taiho, MSD, Seagen, grants and personal fees from Incyte, and nonfinancial support from Pierre Fabre outside the submitted work, as well as reports being a PI of the TransThera (Tinengotinib) phase III trial. A. Gazzah: travel accommodations, congress registration expenses from Boehringer Ingelheim, Novartis, Pfizer, and Roche. Consultant/Expert role for Novartis. Principal/sub-Investigator of Clinical Trials for Aduro Biotech, Agios Pharmaceuticals, Amgen, Argen-X Bvba, Arno Therapeutics, Astex Pharmaceuticals, Astra Zeneca, Aveo, Bayer Healthcare Ag, Bbb Technologies Bv, Beigene, Bioalliance Pharma, Biontech Ag, Blueprint Medicines, Boehringer Ingelheim, Bristol Myers Squibb, Ca, Celgene Corporation, Chugai Pharmaceutical Co., Clovis Oncology, Daiichi Sankyo, Debiopharm S.A., Eisai, Exelixis, Forma, Gamamabs, Genentech, Inc., Gilead Sciences, Inc., GlaxoSmithKline, Glenmark Pharmaceuticals, H3 Biomedicine, Inc., Hoffmann La Roche Ag, Incyte Corporation, Innate Pharma, Iris Servier, Janssen, Kura Oncology, Kyowa Kirin Pharm, Lilly, Loxo Oncology, Lytix Biopharma As, Medimmune, Menarini Ricerche, Merck Sharp & Dohme Chibret, Merrimack Pharmaceuticals, Merus, Millennium Pharmaceuticals, Nanobiotix, Nektar Therapeutics, Novartis Pharma, Octimet Oncology Nv, Oncoethix, Oncomed, Oncopeptides, Onyx Therapeutics, Orion Pharma, Oryzon Genomics, Pfizer, Pharma Mar, Pierre Fabre, Rigontec Gmbh, Roche, Sanofi Aventis, Sierra Oncology, Taiho Pharma, Tesaro, Inc., Tioma Therapeutics, Inc., Xencor. Research Grants from AstraZeneca, BMS, Boehringer Ingelheim, Janssen Cilag, Merck, Novartis, Pfizer, Roche, Sanofi. Non-financial support (drug supplied) from AstraZeneca, Bayer, BMS, Boehringer Ingelheim, Johnson & Johnson, Lilly, Medimmune, Merck, NH TherAGuiX, Pfizer, Roche. D. Planchard: Consulting, advisory role or lectures: AstraZeneca, Bristol Myers Squibb, Boehringer Ingelheim, Celgene, Daiichi Sankyo, Eli Lilly, Merck, MedImmune, Novartis, Pfizer, prIME Oncology, Peer CME, Roche. Honoraria: AstraZeneca, Bristol Myers Squibb, Boehringer Ingelheim, Celgene, Eli Lilly, Merck, Novartis, Pfizer, prIME Oncology, Peer CME, Roche. Clinical trials research as principal or co-investigator (Institutional financial interests): AstraZeneca, Bristol Myers Squibb, Boehringer Ingelheim, Eli Lilly, Merck, Novartis, Pfizer, Roche, Medimmune, Sanofi Aventis, Taiho Pharma, Novocure, and Daiichi Sanky. Travel, Accommodations, Expenses: AstraZeneca, Roche, Novartis, prIME Oncology, Pfizer. M. Aldea: Expenses from Sandoz. No disclosures were reported by the other authors.