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Single cell and spatial analysis of immune-hot and immune-cold tumours identifies fibroblast subtypes associated with distinct immunological niches and positive immunotherapy response

Crossref DOI link: https://doi.org/10.1186/s12943-024-02191-9

Published Online: 2025-01-06

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Jenkins, Benjamin H.

Tracy, Ian

Rodrigues, Maria Fernanda S. D.

Smith, Melanie J. L.

Martinez, Begoña R.

Edmond, Mark

Mahadevan, Sangeetha

Rao, Anjali

Zong, Hailing

Liu, Kai

Aggarwal, Abhishek

Li, Li

Diehl, Lauri

King, Emma V.

Bates, Jamie G.

Hanley, Christopher J.

Thomas, Gareth J.
Funding

Funding for this research was provided by:

AstraZeneca

Pathological Society of Great Britain and Ireland (VF 1002 03)

Sao Paulo Research Foundation (2022/05364-0)

Gilead Sciences

Cancer Research UK Programme grant (DRVRPG-Jun\100004)

Cancer Research UK Centres Network Accelerator Award Grant (A20256)
License Information

Text and Data Mining valid from 2025-01-06

Version of Record valid from 2025-01-06
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Article History

Received: 20 September 2024

Accepted: 30 November 2024

First Online: 6 January 2025

Declarations

:

: Ethical approval for the study was obtained through the UK National Research Ethics Service (South Central - Hampshire B Research Ethics Committee) and written informed consent was obtained from all subjects (REC No. 09/H0501/90).

: The authors declare no competing interests.

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