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LMTK3 regulation of EV biogenesis and cargo sorting promotes tumour growth by reducing monocyte infiltration and driving pro-tumourigenic macrophage polarisation in breast cancer

Crossref DOI link: https://doi.org/10.1186/s12943-025-02346-2

Published Online: 2025-05-23

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Samuels, Mark

Karakostas, Christos

Besta, Simoni

Lauer Betrán, Andrea

Tsilingiri, Katerina

Turner, Charlotte

Shirazi Nia, Reza

Poudine, Niloufar

Goodyear, Richard

Jones, William

Klinakis, Apostolos

Giamas, Georgios
Funding

Funding for this research was provided by:

Action Against Cancer (G1828)
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Article History

Received: 9 January 2025

Accepted: 28 April 2025

First Online: 23 May 2025

Declarations

:

: The research in this study using PBMCs was approved by the research ethics committee of Sciences and Technology (C-REC) at the University of Sussex (Reference Number: ER/MS2207/1) on the 14 th of June 2023. Written informed consent was obtained from all study participants.The animal studies were conducted in in the Animal House Facility of the Biomedical Research Foundation of the Academy of Athens (BRFAA, Greece). All procedures for the care and treatment of the animals were approved by the Institutional Committee on Ethics of Animal Experiments, and studies were conducted in full compliance with FELASA (Federation of Laboratory Animal Science Associations) recommendations. Ethics number: 1385947/27–12-2022.The 4T1 mouse model was conducted in the animal experiment centre of Zhejiang Chinese Medicine University. Mouse experiments were approved by the Experimental Animal Ethics Committee of Zhejiang Chinese Medicine University (approval number: IACUC-20250120–18).

: Not applicable.

: The authors declare no competing interests.

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