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Authors
Murakami, Kosuke
Takamura, Shiki
Miyagawa, Chiho
Takamatsu, Shiro
Kashima, Yoko
Nagaoka, Koji
Kobayashi, Yukari
Hakata, Yoshiyuki
Kato, Shigeki
Tsuji-Kawahara, Sachiyo
Nan, Ding
Chandler, Ronald
Takahashi, Satoru
Miyazawa, Masaaki
Kakimi, Kazuhiro
Matsumura, Noriomi
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Funding
Funding for this research was provided by:
Japan Society for the Promotion of Science (19K18684)
Japan Society for the Promotion of Science (23K27431)
Japan Society for the Promotion of Science (23K08879)
Japan Society for the Promotion of Science (20K21665)
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Article History
Received: 14 March 2026
Accepted: 22 June 2026
First Online: 30 June 2026
Declarations
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: This study was conducted with the approval of the Institutional Review Board of Kindai University Faculty of Medicine (R03-084), and Kyoto University Graduate School and Faculty of Medicine (G531). Patients in this study were given an appropriate opportunity to refuse to participate in the study by opt-out on the website of Kindai University Faculty of Medicine ( ), and Kyoto University Graduate School and Faculty of Medicine ( ). This study was performed in accordance with the Declaration of Helsinki. Animal experiments were approved by Kindai University and the Animal Experiment Committee of Kindai University (KDMS-2021–004, KAME-2024–024).
: Not applicable.
: Kosuke Murakami received a research grant from Eisai. Noriomi Matsumura received lecture fees from Chugai Pharmaceutical, AstraZeneca, and Takeda Pharmaceutical, as well as a research grant from AstraZeneca. Noriomi Matsumura is also an outside director of Takara Bio. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
