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Article History

Received: 27 March 2024

Accepted: 16 September 2024

First Online: 18 October 2024

Declarations

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: The reason for using animals is that research requires them to develop new therapies for treating diseases. We conducted tests on animals to observe whether HA-PEG-UA NPs are safe and effective against SAH mice. A total of 226 C57 BL/6 male mice were used, with an average age of 8 weeks and a body weight between 22-26 g. All mice were purchased from China Slake Experimental Animal Co., Ltd. The mice were kept at a constant temperature under a 12 h dark light cycle, and were fed freely with water and standard laboratory feed. Conduct the experiment after one week of adaptation. At the end of study, the animals were sacrificed with cervical dislocation method following anesthesia with 1.5% isoflurane. The Laboratory Animal Ethics Committee of Renmin Hospital of Wuhan University approved all experiments with animals in this study (WDRY20210305A). All methods are reported in accordance with ARRIVE guidelines.

: Not applicable.

: The authors declare no competing interests.