Document is current
Any future updates will be listed below
-
Authors
You, Yi
Gao, Linrui
Li, Shijia
Huang, Hui
Wang, Tierun
Nie, Zongchang
Zhou, Jian
Ma, Xiaoxue
Li, Jiarui
Bie, Hongyu
Zhang, Tian
Chen, Xi
Pang, Qingsong
Wang, Ping
Yan, Cihui
Zhang, Wencheng
-
Funding
Funding for this research was provided by:
National Natural Science Foundation of China (82272733)
National Natural Science Foundation of China (82272733)
National Natural Science Foundation of China (82272733)
National Natural Science Foundation of China (82272733)
National Natural Science Foundation of China (82272733)
National Natural Science Foundation of China (82272733)
National Natural Science Foundation of China (82273083)
National Natural Science Foundation of China (82272733)
National Natural Science Foundation of China (82273083)
National Natural Science Foundation of China (82273083)
National Natural Science Foundation of China (82272733)
National Natural Science Foundation of China (82272733)
National Natural Science Foundation of China (82272733)
National Natural Science Foundation of China (82272733)
National Natural Science Foundation of China (82273083)
National Natural Science Foundation of China (82272733)
State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine (QZ23-9)
State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine (QZ23-9)
State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine (QZ23-9)
State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine (QZ23-9)
State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine (QZ23-9)
State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine (QZ23-9)
State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine (QZ23-9)
State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine (QZ23-9)
State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine (QZ23-9)
State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine (QZ23-9)
State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine (QZ23-9)
State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine (QZ23-9)
Tianjin Key Medical Discipline Construction Project (TJYXZDXK-3-004B)
Tianjin Key Medical Discipline Construction Project (TJYXZDXK-3-004B)
- License Information
-
More Information
Article History
Received: 5 March 2025
Accepted: 19 November 2025
First Online: 1 December 2025
Declarations
:
: All patients gave informed consent. The study was approved by the Institutional Review Board and Ethics Committee of Tianjin Medical University Cancer Institute & Hospital (bc2023192). This study is not a clinical trial, but it uses clinical samples and data from three clinical trials. The information for the three clinical trials is as follows: NCT03671265, Registry: Tianjin Medical University Cancer Institute and Hospital, Registration Date: 2018-09-17; NCT03222440, Registry: Tianjin Medical University Cancer Institute and Hospital, Registration Date: 2017-07-19; NCT04807673, Registry: Tianjin Medical University Cancer Institute and Hospital, Registration Date: 2021-12-01.
: All animal experiments were approved by the Institutional Animal Care and Use Committee（IACUC）of Tianjin Medical University (Doc.No:TMUaMEC2023004). The ethics committee requires that the tumor volume of mice bearing tumors should not exceed one-tenth of their body weight. This study meets the above requirements.
: Not applicable.
: The authors declare no competing interests. The graphical abstract was created in BioRender.
