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Mesenchymal stem cell-derived apoptotic extracellular vesicles loaded with Prussian blue nanoparticles attenuate severe acute pancreatitis via neutrophil extracellular traps resolution and acinar-ductal metaplasia promotion

Crossref DOI link: https://doi.org/10.1186/s12951-025-03958-y

Published Online: 2025-12-25

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Xu, Wenjie

Cai, Wenwu

Wu, Junyong

Hou, Xuyang

Qi, Xiaoyan

Wei, Zuxing

Cheng, Yimiao

Zheng, Yanwen

Cui, Beibei

He, Jun
Funding

Funding for this research was provided by:

Natural Science Foundation of Hunan Province (2023JJ40821)

Natural Science Foundation of Hunan Province (2023JJ40821)

Natural Science Foundation of Hunan Province (2023JJ40821)

Natural Science Foundation of Hunan Province (2023JJ40821)

Natural Science Foundation of Hunan Province (2023JJ40821)

Natural Science Foundation of Hunan Province (2023JJ40821)

Natural Science Foundation of Hunan Province (2023JJ40821)

Natural Science Foundation of Hunan Province (2023JJ40821)

Natural Science Foundation of Hunan Province (2023JJ40821)

Natural Science Foundation of Hunan Province (2023JJ40821)

Changsha Natural Science Foundation (kq2208308)

Changsha Natural Science Foundation (kq2208308)

Changsha Natural Science Foundation (kq2208308)

Changsha Natural Science Foundation (kq2208308)

Changsha Natural Science Foundation (kq2208308)

Changsha Natural Science Foundation (kq2208308)

Changsha Natural Science Foundation (kq2208308)

Changsha Natural Science Foundation (kq2208308)

Changsha Natural Science Foundation (kq2208308)

Changsha Natural Science Foundation (kq2208308)

Hunan Provincial Health Commission Health Research Project (W20243029)

Hunan Provincial Health Commission Health Research Project (W20243029)

Hunan Provincial Health Commission Health Research Project (W20243029)

Hunan Provincial Health Commission Health Research Project (W20243029)

Hunan Provincial Health Commission Health Research Project (W20243029)

Hunan Provincial Health Commission Health Research Project (W20243029)

Hunan Provincial Health Commission Health Research Project (W20243029)

Hunan Provincial Health Commission Health Research Project (W20243029)

Hunan Provincial Health Commission Health Research Project (W20243029)

Hunan Provincial Health Commission Health Research Project (W20243029)
License Information

Text and Data Mining valid from 2025-12-25

Version of Record valid from 2025-12-30
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Article History

Received: 3 June 2025

Accepted: 14 December 2025

First Online: 25 December 2025

Declarations

:

: This study did not involve any human participants, human data or human tissues. And all animal experiments were performed after obtaining approval (No.20231282) from the Ethics Committee of the Second Xiangya Hospital of Central South University, with minimal animal suffering.

: All authors agree to the publication of the article.

: The authors declare no competing interests.

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