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Clusterzymes-driven therapy: ultrasmall Cu4 nanoclusters achieve dual-pronged synergistic effects on antioxidant defense and ferroptosis Inhibition for inflammatory osteolysis

Crossref DOI link: https://doi.org/10.1186/s12951-025-04009-2

Published Online: 2026-01-21

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Wang, Yucheng

Han, Zeyu

Hao, Guanghua

Cheng, Han

Dai, Fengrong

Chen, Xuzhuo

Shi, Bin
Funding

Funding for this research was provided by:

the National Natural Science Foundation of China (Nos. 82301108, and 82370979)

Fujian Provincial Department of Science and Technology International Cooperation Project (2024I0014)
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Text and Data Mining valid from 2026-01-21

Version of Record valid from 2026-01-29
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Article History

Received: 12 September 2025

Accepted: 29 December 2025

First Online: 21 January 2026

Declarations

:

: All the experimental procedures that had been conducted adhered to ethical guidelines and were approved by the Animal Care and Experiment Committee of the Ninth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine (No. SH9H-2025-A1623-1).

: All authors read and approved the final manuscript.

: The authors declare no competing interests.

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