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Ultrasound-responsive biomimetic nanocarrier triggers spatiotemporal PROTAC release and ROS storm to disrupt TNBC immunosuppression via coordinated apoptosis/ferroptosis/senescence activation

Crossref DOI link: https://doi.org/10.1186/s12951-026-04578-w

Published Online: 2026-05-23

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Liao, Zhipeng

Liao, Haiqin

Luo, Yi

Chen, Sihan

Shen, Yuanyuan

Zhang, Ming

Xu, Yan

Wang, Long

Niu, Chengcheng
Funding

Funding for this research was provided by:

Hunan Provincial Natural Science Foundation of China (2023JJ30804)

National Natural Science Foundation of China (82572252)
License Information

Text and Data Mining valid from 2026-05-23

Accepted Manuscript valid from 2026-05-23
More Information

Article History

Received: 25 February 2026

Accepted: 13 May 2026

First Online: 23 May 2026

Declarations

:

: All animal experiments were conducted in strict accordance with ARRIVE guidelines and approved by the Ethics Committee of the Second Xiangya Hospital, Central South University (20250090).

: All authors have approved the manuscript and agree for the submission.

: The authors declare no competing interests.

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