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Article History

Received: 19 March 2018

Accepted: 11 September 2018

First Online: 20 September 2018

Ethics approval and consent to participate

: All procedures performed in studies involving human participants were in accordance with the ethical standards of the South West-Cornwall & Plymouth Research Ethics Committee (17/SW/0092) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants included in the study.

: Not applicable

: TJ has received honoraria and consultancy fees from Astra Zeneca and Daiichi-Sankyo. All other authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript, except support from a government grant as detailed in the funding declaration. This includes employment, consultancies, grants, honoraria, stock ownership or options, expert testimony, or patents received or pending royalties. No writing assistance was utilised in the production of this manuscript.

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