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Article History

Received: 16 July 2025

Accepted: 29 September 2025

First Online: 24 December 2025

Declarations

:

: The PERSEUS study was reviewed by the institutional medical ethical committee of the Amsterdam UMC and declared to be not subject to the Dutch Medical Research Involving Human Subjects Act (2021.0362). The study was conducted according to the Declaration of Helsinki. All participants gave written informed consent. The use of Castor EDC software was in line with the European Union’s General Data Protection Regulation.

: Not applicable.

: HWMvL reports an advisory role for AMphera, Anocca, Astellas, AstraZeneca, Beigene, Boehringer, Daiichy-Sankyo, Dragonfly, Eli Lilly, MSD, Myeloid, Nordic Pharma, Servier, has received research funding, medication supply and/or research support from Auristone, Bayer, BMS, Celgene, Eli Lilly, Janssen, Incyte, Merck, MSD, Nordic Pharma, ORCA, Philips, Roche and Servier, and has had a speaker role at Astellas, Beigene, Benecke, BMS, Daiichy-Sankyo, JAAP, Medtalks, Novartis, Springer, Travel Congress Management BV. All fees were paid to the institution. MFB has received research funding from Celgene, Frame Therapeutics, and Lead Pharma, and has acted as a consultant to Servier, Olympus and Wholomics. JWW reports an advisory role for MSD, Astra Zeneca and Servier, and has received grants of MSD, Servier and Nordic. MGB has received research funding from Intuitive Surgical, Oncosil, Medtronic, and Ethicon. JdVG has served as a consultant for Amgen, AstraZeneca, MSD, Pierre Fabre, and Servier, and has received institutional research funding from Servier. All outside the submitted work. MFL, IPS, ENvA, SA, IJMF, IQM, MYVH, IHJTdH, BAB, BCH, PAJV, PTN, and GWJF report no conflicts of interests.