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Article History

Received: 22 August 2018

Accepted: 19 October 2018

First Online: 7 November 2018

Ethics approval and consent to participate

: The study using human tumor samples was conducted under the national regulative law for the handling of biological specimens from tumor banks, being the samples exclusively available for research purposes in retrospective studies, as well as under the international Helsinki declaration.Animal experiments were carried out in accordance with the European Guidelines for the Care and Use of Laboratory Animals, Directive 2010/63/UE and the National Regulation published in 2013 (Decreto-Lei n.° 113/2013 de 7 de Agosto). All experimental procedures were approved by ORBEA (Orgão Responsável pelo Bem-Estar Animal da Faculdade de Medicina da Universidade do Porto/Animal Welfare Body of the Medical Faculty of the University of Porto).

: We have obtained consent to publish this paper from the participants of this study.

: The authors declare that have no competing interests.

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