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The CCL5/CCR5/SHP2 axis sustains Stat1 phosphorylation and activates NF-κB signaling promoting M1 macrophage polarization and exacerbating chronic prostatic inflammation

Crossref DOI link: https://doi.org/10.1186/s12964-024-01943-w

Published Online: 2024-12-05

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Jin, Chen

Zhang, Fei

Luo, Hailang

Li, Boyang

Jiang, Xue

Pirozzi, Christopher J.

Liang, Chaozhao

Zhang, Meng
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Text and Data Mining valid from 2024-12-05

Version of Record valid from 2024-12-05
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Article History

Received: 19 October 2024

Accepted: 13 November 2024

First Online: 5 December 2024

Declarations

:

: All procedures involving human participants, including obtaining written informed consent, were conducted in accordance with the principles outlined in the Helsinki Declaration and were approved by the Ethics Committee of the First Affiliated Hospital of Anhui Medical University on June 10, 2020 (PJ-2020–07-11). Written informed consent was obtained from all participants involved in this study. All animal experiments were conducted in compliance with the guidelines of the Animal Care and Utilization Committee of the Animal Center of Anhui Medical University, with approval (approval no. LLSC20241750).

: Informed consent for publication was obtained from all participants involved in the study.

: The authors declare no competing interests.

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