Crossmark

Cullin-RING ligase BioE3 reveals molecular-glue-induced neosubstrates and rewiring of the endogenous Cereblon ubiquitome

Crossref DOI link: https://doi.org/10.1186/s12964-025-02091-5

Published Online: 2025-02-19

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Merino-Cacho, Laura

Barroso-Gomila, Orhi

Pozo-Rodríguez, Mónica

Muratore, Veronica

Guinea-Pérez, Claudia

Serrano, Álvaro

Pérez, Coralia

Cano-López, Sandra

Urcullu, Ainhoa

Azkargorta, Mikel

Iloro, Ibon

Galdeano, Carles

Juárez-Jiménez, Jordi

Mayor, Ugo

Elortza, Felix

Barrio, Rosa

Sutherland, James D.
Funding

Funding for this research was provided by:

Ministerio de Universidades (FPU20/05282)

HORIZON EUROPE Marie Sklodowska-Curie Actions (765445-EU, UbiCODE Program)

HORIZON EUROPE Marie Sklodowska-Curie Actions (765445-EU, UbiCODE Program)

HORIZON EUROPE Marie Sklodowska-Curie Actions (765445-EU, UbiCODE Program)

Ministerio de Ciencia e Innovación (PRE2022-104553)

Ministerio de Ciencia e Innovación (PRE2018-086230)

Ministerio de Ciencia e Innovación (PRE2021-099359)

Ministerio de Ciencia e Innovación (PREP2023-000294)

Cooperation for Science & Technology COST Action (ProteoCure CA20113)

Cooperation for Science & Technology COST Action (ProteoCure CA20113)

Cooperation for Science & Technology COST Action (ProteoCure CA20113)

Cooperation for Science & Technology COST Action (ProteoCure CA20113)

Computational Biology Drug Design Consolidated Research Group, Generalitat de Catalunya (2021SGR00671)

Computational Biology Drug Design Consolidated Research Group, Generalitat de Catalunya (2021SGR00671)

Ministerio de Ciencia, Innovación y Universidades (CNS2022-135307)

Ministerio de Ciencia, Innovación y Universidades (PID2020-117333GB-I00)

Ministerio de Ciencia, Innovación y Universidades (PID2023-147399NB-I00, PID2020-114178GB-I00, CEX2021-001136-S, CEX2021-001202-M)

Ministerio de Ciencia, Innovación y Universidades (PID2023-147399NB-I00, PID2020-114178GB-I00, CEX2021-001136-S, CEX2021-001202-M)

European Union NextGeneration EU/PRTR

Red Española de Supercomputación (BCV-2021-3-0006, BCV-2021-2-0005)

Diputación Foral de Bizkaia (6/12/TT/2023 /00001)

Diputación Foral de Bizkaia (6/12/TT/2023 /00001)
License Information

Text and Data Mining valid from 2025-02-19

Version of Record valid from 2025-02-19
More Information

Article History

Received: 25 October 2024

Accepted: 8 February 2025

First Online: 19 February 2025

Declarations

:

: Not applicable.

: Not applicable.

: C.G. is co-founder and Drug Discovery Scientific Advisor of Oniria Therapeutics. The other authors declare that they have no competing interests.

Document is current

Any future updates will be listed below